Dr. Rhonda Patrick on health: what the evidence says · JRE #901
SUBJECT: HEALTH
Not a true/false call. Every claim is logged with its sources; read the exhibits below.
there's been a human clinical trial done uh with nicotinamide riboside and that just to show that it's safe and that it actually does increase nad levels in in human blood which it does um even even as low as a 100 milligrams dose a day
What the evidence says 01 / RECORD
Patrick's specific factual claim, that a human clinical trial showed nicotinamide riboside (NR) to be safe and to raise blood NAD+ levels at doses as low as 100 mg/day, matches the peer-reviewed literature available at the time. Trammell et al. (2016, Nature Communications) reported the first controlled human pharmacokinetic trial of NR, giving healthy adults single oral doses of 100, 300, and 1,000 mg; all doses, including 100 mg, produced a measurable, dose-dependent rise in the blood NAD+ metabolome, and no serious adverse events occurred across 36 days of observation. A University of Iowa press release on the same study likewise states NR "safely boosts human NAD+ metabolism" with no serious side effects at any dose tested. This narrow safety/biomarker claim is well-supported; it is separate from, and should not be conflated with, the extensive mouse anti-aging and disease-reversal findings Patrick discusses elsewhere in the same segment, since no human trial existing at the time of this 2016-era study had demonstrated equivalent functional anti-aging or disease outcomes in people.