Dr. Rhonda Patrick on alzheimer's: what the evidence says · JRE #1178
SUBJECT: ALZHEIMER'S
Not a true/false call. Every claim is logged with its sources; read the exhibits below.
So it certainly seems very interesting that he's actually been able to not only like delay Alzheimer's disease, but reverse it.
What the evidence says 01 / RECORD
Dr. Dale Bredesen has published case series, most notably a 2014 report of 10 patients, claiming cognitive improvement or reversal using a multi-component "MEND"/ReCODE lifestyle and supplement program. That original study was an uncontrolled case series with no comparison group, and the authors themselves stated a larger, controlled trial was needed to validate the findings. A UCSF neurologist's published review of Bredesen's papers found the studies lacked placebo controls, omitted key methodological details (protocol procedures, participant criteria, information on non-responders), appeared in low-oversight open-access journals, and had at least one undisclosed financial conflict of interest; the reviewer concluded there is no evidence that the intensive, costly regimen reverses or prevents Alzheimer's disease beyond standard, already-recommended measures like exercise and a Mediterranean diet. As of mid-2026, no large, blinded, placebo-controlled trial has confirmed disease reversal, and mainstream Alzheimer's specialists do not accept that the protocol reverses the underlying disease. The evidentiary basis for Patrick's claim is small uncontrolled case series, not confirmed reversal of Alzheimer's disease.