Mary Talley Bowden on ivermectin: what the evidence says · JRE #2335
SUBJECT: IVERMECTIN
Not a true/false call. Every claim is logged with its sources; read the exhibits below.
So for ivermectin, it kind of depends on the rat, I mean, the type of animal and the gender, but it's basically 10 milligrams per kilogram up to 80 milligrams per kilogram. So for COVID, we're using 0.4
What the evidence says 01 / RECORD
Published toxicology data put ivermectin's acute oral LD50 in rodents in roughly the range Bowden cites, with reported values that vary widely by species and sex: pharmacology reviews list about 25 mg/kg in mice and about 50 mg/kg in adult rats, and WHO and other datasets span from roughly 11.6 mg/kg to 40 mg/kg or higher in mice, so her 10 to 80 mg/kg framing is broadly consistent with the literature. Her stated human COVID dose of 0.4 mg/kg is also accurate as a description of what protocols used: reviews describe 0.2 to 0.4 mg/kg as the usual antiparasitic dose considered extremely safe in humans. The numbers she gives, and her underlying point that lethal animal doses far exceed the 0.4 mg/kg human dose, are correct. Context worth noting: this favorable safety margin does not mean ivermectin works for COVID, as large randomized trials found no consistent clinical benefit. On the specific figures cited, the claim is largely accurate.
Who Benefits
Bowden is a physician who prescribes ivermectin to patients for COVID, is affiliated with groups promoting the drug, and is now permitted to sell it, giving her a professional and financial interest in portraying ivermectin as safe.